Causes of IVF Failure

Causes of IVF Failure?

It is not always possible to obtain successful results in IVF trials. The most important factor to be considered when evaluating the success rates in IVF is the age of the woman. Failure rates increase as women age. The most important reason for this is that genetic disorders are seen more frequently in eggs with the progression of age. However, even in young couples, although everything seems normal, pregnancy may not occur even with IVF treatment. At this point, although suggestions such as ‘Fate, Sans, Destiny’ can be made due to the fact that medicine cannot explain everything, the recommendation of medical scientists is to try again. The most important point to be considered here is to learn from the first attempt and to try to be more successful in the second trial by carefully examining the response of that couple in the first trial. In the new trial, the effects of the first trial on egg development and embryo development are evaluated in detail.

IVF Failure

It is the situation where pregnancy cannot be achieved in 3 or more IVF applications despite good quality embryo transfer (10 or more). IVF failure may be caused by the following conditions.

1) Hydrosalpenx (fluid accumulation in the tubes) should be investigated. In the presence of hydrosalpenx, the tube should be removed laparoscopically as part of preparation before in vitro fertilization.

2) Intrauterine evaluation. It should be shown that there is no problem in the uterus by ultrasonography, uterine tube film (HSG), if necessary, hysteroscopy.

3) Myoma. It is the hysteroscopic removal of fibroids (submucous) that have grown into the uterus before IVF. The effects of fibroids that do not press into the uterus on IVF success are controversial. However, some studies have reported that fibroids larger than 4-5 cm in diameter may have negative effects on pregnancy rates in IVF, even if they do not put pressure on the inner layer of the uterus.

4) Applied treatment protocols are reviewed. The effects of doses and protocols on embryo quality and the inner wall of the uterus are reviewed again. Previous treatment protocols and the results obtained are examined in detail, and clues are sought in the selection of a new approach.

5) Checking the coagulation factors in women

6) Genetic tests of mother and father candidates

7) To reveal the detailed endocrinological and metabolic status of the woman.

8) Personalization of the new treatment option as much as possible

9) Application of laboratory and clinically proven support methods

10) Maximum attention to the embryo transfer process and arranging post-transfer support treatments

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